A controlled trial was instituted to compare the effect on intraocular pressure of topical administration of timolol maleate with epinephrine hydrochloride. A bottling error by the manufacturer resulted in the placebo bottles containing 1.5% timolol maleate. This drug given twice a day for two weeks significantly reduced intraocular pressure and produced no side effects.
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Ritch et al. (1978) studied this question.
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