Key result
Low-dose latrunculin B induced a several-fold increase in free G-actin, which promoted mDia1-catalyzed actin nucleation to execute rapid reassembly of actin filaments.
Transient accumulation of G-actin acts as a cue to promote mDia1-catalyzed actin nucleation for rapid reassembly of actin filaments.
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G-actin signaling in actin repair extends cell biology mechanisms; leaves open validation in cardiovascular models.
Higashida et al. (2008) studied this question. Latrunculin B (LatB) was evaluated on Actin nucleation frequency of mDia1. Low-dose latrunculin B induced a several-fold increase in free G-actin, which promoted mDia1-catalyzed actin nucleation to execute rapid reassembly of actin filaments.
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