Tandem Palladium(0) and Palladium(II)‐Catalyzed Allylic Alkylation Through Complementary Redox Cycles

Here it goes again: A tandem catalytic process effects sequential Pd0-catalyzed allylic alkylations through leaving group ionization and PdII-catalyzed allylic alkylations by CH activation. By employing an oxidative trigger to convert the catalytic species from Pd0 into PdII, both transformations can be conducted in a single reaction vessel using the same precatalyst. This allows for the selective introduction of otherwise indistinguishable allyl groups.