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Radioimmunoassay of plasma aldosterone has been simplified by the elimination of the chromatographic purification step. A neutral plasma extract is subjected to water/toluene partition and oxidation with periodic acid and the neutral etiolactone product assayed with an aldosterone antiserum which cross-reacts with the etiolactone. Aldosterone concentrations in human plasma determined by this procedure agree with values obtained by other methods.
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Varsano-Aharon et al. (1973) studied this question.
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