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Laurocerasus officinalis is a popular black summer fruit and it belongs to Prunus genus and Rosaceae family. L. officinalis has many biological activities, such as anti-inflammatory, antinociceptive, antioxidant, neuroprotective, antidiabetic, among others. The aim of the current study was to determine the antioxidant activity and cytotoxic effects of dimethyl sulfoxide extract of L. officinalis (DEL). Total polyphenolic content and cytotoxic activity of DEL was investigated using Folin-Ciocalteu method and MTT assay, respectively. Total polyphenolic content of DEL was found 33.7±0.13 mg gallic acid equivalent/g fruit powder. DEL exhibited selective cytotoxic effect against four human cancer (lung, colon, liver and cervix) cell lines. The predominant selective cytotoxic effect of DEL was observed against colon cancer cells (IC 50 =265.2±8.1 µg/mL) compared to normal fibroblast cells. These data demonstrate that L. officinalis extract exhibited selective cytotoxicity towards some cancer cells. To clarify the effective molecules and their mechanisms, further studies are needed to undertaken.
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Demir et al. (2016) studied this question.
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