Extra-corporeal perfusion was utilized during the surgical repair of congenital cardiovascular abnormalities in a twenty-four-hour-old neonate. Modifications of standard perfusion techniques are described. The need to monitor and carefully control the oxygen tension is discussed. High oxygen tension has been linked to retrolental fibroplasia (RLF) in neonates, and high oxygen tension can occur during extra-corporeal circulation. It is a logical precaution to keep the partial pressure of oxygen as close to normal as possible when perfusing neonates. The theoretical relationship between extra-corporeal oxygen exposure and RLF in neonates during open-heart surgery is discussed.
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Cappola et al. (1981) studied this question.
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