Mesotherapy Using Vitamin C and Platelet Rich Plasma as an Anti-inflammatory Agent in Persistent Gingival Inflammation: A Pilot Study

In mesotherapy, the recipient receives minor dosages of biologically active substances in an area of pathology, which are delivered to the skin via local intradermal therapy (LIT). In addition to their anti-inflammatory properties, vitamin C and platelet-rich plasma (PRP) can improve tissue repair and reduce inflammation. Aim: This study examined whether local injections of vitamin C and PRP could be used to treat persistent gingival inflammation. Materials and methods: Following phase-I therapy, 15 patients with chronic persistent gingival inflammation underwent PRP and vitamin C injections respectively into the gingiva. Each patient underwent a weekly evaluation to see if the inflammation had subsided. Results: During recall visits, the inflammation of the injected sites showed a significant improvement in post clinical pictures. Conclusions: Local intradermal therapy (LIT) with vitamin C and PRP has a synergistic interaction along with scaling and root planing in the treatment of persistent gingival inflammation.