Mesotherapy using Vitamin C and platelet-rich plasma as an antiinflammatory agent in persistent gingival inflammation: A pilot study

Introduction: In mesotherapy, the recipient receives minor dosages of biologically active substances in an area of pathology, which are delivered into the skin through local intradermal therapy (LIT). In addition to its anti-inflammatory properties, Vitamin C and platelet-rich plasma (PRP) can improve tissue repair and reduce inflammation. Aim: This study examined whether local injections of Vitamin C and PRP could be used to treat persistent gingival inflammation. Materials and Methods: Following Phase I therapy, 15 patients with chronic persistent gingival inflammation underwent PRP and Vitamin C injections, respectively, into the gingiva. Each patient underwent a weekly evaluation to see if the inflammation had subsided. Results: During recall visits, the inflammation of the injected sites showed a significant improvement in postclinical pictures. Conclusions: LIT with Vitamin C and PRP has a synergistic interaction along with scaling and root planing in the treatment of persistent gingival inflammation.