Efficient preparation of substituted 5,6,7,8-tetrahydroquinolines and octahydroacridine derivatives

The reaction of the enamine 4 with different β-amino ketone hydrochlorides 3a–e affords the diketones 5a–e which can be cyclized to the corresponding mono- and disubstituted tetrahydroquinolines 6a–e. Furthermore the preparation of the octahydroacridines 8f and 8g by using a straightforward multi step sequence is described.