Key result
A 40-year-old female with undiagnosed Graves' disease successfully recovered from thyrotoxic periodic paralysis and thyroid storm triggered by a liver abscess following medical management.
Case Report (n=1)
This case highlights a rare presentation of Graves' disease manifesting as thyrotoxic periodic paralysis and thyroid storm triggered by a liver abscess in a female patient.
Acute flaccid quadriplegia may signal thyroid storm in undiagnosed Graves' even in females; this case leaves open infection as a trigger.
Thyrotoxic periodic paralysis is a rare endocrine emergency that manifests as acute onset muscle weakness and hypokalaemia secondary to thyrotoxicosis. It mainly occurs due to rapid and dramatic intracellular shift of potassium resulting in hypokalaemia and acute flaccid paralysis. This condition predominantly affects males of Asian descent, and presentation can range from mild generalized weakness to complete quadriplegia, as seen in our case. We herein report a case of a 40-year-old female, who presented to us with acute onset flaccid quadriplegia and thyroid storm, which is the first ever manifestation of previously undiagnosed Grave's disease. Liver abscess was found to be the underlying trigger for thyrotoxic paralysis and thyroid storm.
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Banavathu et al. (2021) conducted a case report in Thyrotoxic Periodic Paralysis and Thyroid Storm (n=1). Propylthiouracil, propranolol, hydrocortisone, and potassium supplementation was evaluated on Clinical recovery. A 40-year-old female with undiagnosed Graves' disease successfully recovered from thyrotoxic periodic paralysis and thyroid storm triggered by a liver abscess following medical management.
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