Key result
Pimozide, calmidazolium, and veratridine blocked Ca2+ channels in rat pituitary GH4C1 cells, with pimozide inhibiting Ca2+ uptake and prolactin secretion half-maximally at 100 nM.
Population
Rat pituitary GH4C1 cell line
Design
Preclinical
Authors
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Caution against assuming effects on prolactin in patients; extends in vitro pharmacology but leaves open human relevance.
Ca2+ channels in pituitary endocrine cells can be blocked by various molecules including sodium channel toxins and calmodulin antagonists, demonstrating pharmacological similarities with other excitable cells.
Enyeart et al. (1987) studied this question. Pimozide, calmidazolium, and veratridine vs. Conventional Ca2+ antagonists (nitrendipine, verapamil, diltiazem) was evaluated on Inhibition of depolarization-dependent 45Ca2+ uptake and prolactin secretion. Pimozide, calmidazolium, and veratridine blocked Ca2+ channels in rat pituitary GH4C1 cells, with pimozide inhibiting Ca2+ uptake and prolactin secretion half-maximally at 100 nM.
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