Key result
Neuroleptic drugs, including pimozide, penfluridol, chlorpromazine, and haloperidol, act as calcium channel blockers in vascular smooth muscle but are not selective for voltage-sensitive channels.
Why the study?
Do neuroleptic drugs attenuate calcium influx and tension development in isolated rabbit thoracic aorta?
Do neuroleptic drugs attenuate calcium influx and tension development in isolated rabbit thoracic aorta?
Neuroleptic drugs from three different classes demonstrate calcium channel blocking activity in vascular smooth muscle, suggesting a potential mechanism involving a calcium-binding protein in the calcium channel.
Answers are grounded in this paper and cite their sources.
Neuroleptic calcium channel effects in rabbit aorta warrant clinical caution; leaves open relevance and selectivity in human vasculature.
This study was designed to determine whether neuroleptic drugs have calcium channel blocking activity in isolated rings of rabbit thoracic aorta. The results confirm previous findings that pimozide and penfluridol are calcium channel blockers. However, the data do not support the conclusion that these agents are selective for the voltage-sensitive calcium channel. The results also show that both haloperidol and chlorpromazine (which represent different classes of neuroleptic drugs) are also calcium channel blockers in vascular smooth muscle.
No takes yet. Share an insight, caveat, or question.
Flaim et al. (1985) studied this question. Neuroleptic drugs (pimozide, penfluridol, chlorpromazine, haloperidol) was evaluated on Calcium channel blocking activity. Neuroleptic drugs, including pimozide, penfluridol, chlorpromazine, and haloperidol, act as calcium channel blockers in vascular smooth muscle but are not selective for voltage-sensitive channels.
Synapse has enriched 10 related papers. Consider them for comparative context: