September 1, 1996Anesthesiology

Direct Inhibitory Effect of Chlorpromazine on Smooth Muscle of the Porcine Pulmonary Artery

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Why the study?

Does chlorpromazine inhibit intracellular Ca2+ elevation and force in porcine pulmonary arterial smooth muscle?

Population

Porcine pulmonary arterial strips and aortic membranes

Comparison

Chlorpromazine (up to 1 microM) vs Control or other neuroleptics in binding studies

Design

Preclinical

Authors

CSChie SakiharaFukuoka Institute of Technology JNJunji NishimuraFukuoka Institute of Technology SKSei KobayashiShowa University

Discussion

Member takes

Implication

May inform mechanisms of pulmonary vasorelaxation in animal models; leaves open clinical translation to human disease.

Structured PICO

Does chlorpromazine inhibit intracellular Ca2+ elevation and force in porcine pulmonary arterial smooth muscle?

Population

Porcine pulmonary arterial strips and aortic membranes

Intervention

Chlorpromazine (up to 1 microM)

Comparator

Control (no chlorpromazine) or other neuroleptics (haloperidol, phentolamine, trifluoperazine, imipramine) in binding studies

Outcome

Intracellular Ca2+ concentration ([Ca2+]i) and force of vascular smooth musclesurrogate

Chlorpromazine induces vasorelaxation primarily through alpha-adrenergic blockade and calcium antagonism in porcine pulmonary arteries.

Cite This Study

Sakihara et al. (1996) studied this question.

synapsesocial.com/papers/6a870ee2b712452940cbb551 https://doi.org/10.1097/00000542-199609000-00022

View Full Paper

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Direct Inhibitory Effect of Chlorpromazine on Smooth Muscle of the Porcine Pulmonary Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct Inhibitory Effect of Chlorpromazine on Smooth Muscle of the Porcine Pulmonary Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider