January 1, 2010Journal of Smooth Muscle ResearchOpen Access

Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery

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Population

Porcine coronary artery, carotid artery, and aorta models

Design

Preclinical

Authors

TKT KanedaNippon Veterinary and Life Science University TKTakashi KubôtaTeikyo Heisei University KFKenji FujimotoKanazawa University

Discussion

Member takes

Implication

May support PDE4 inhibition for coronary relaxation in models; leaves open translation to human disease.

Structured PICO

Population

Porcine coronary artery, carotid artery, and aorta models

Intervention

Selective phosphodiesterase (PDE) inhibitors including rolipram (type 4), vinpocetine (type 1), EHNA (type 2), milrinone (type 3), Ro20-1724 (type 4), and zaprinast (type 5)

Outcome

Muscle contractility (U46619-induced contractions) and cyclic nucleotide content (cAMP, cGMP)surrogate

Rolipram potently relaxes porcine coronary arteries by decreasing intracellular calcium levels and altering calcium sensitivity via cAMP.

Cite This Study

Kaneda et al. (2010) studied this question.

synapsesocial.com/papers/6a90ded5f69e67dea43609b3 https://doi.org/10.1540/jsmr.46.17

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Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider