Population
Guinea pig left atria
Comparison
Selective PDE IV inhibitors at 0.1-30 microM… vs Control levels and PDE III inhibitors
Design
Preclinical
Authors
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No immediate clinical implications; leaves open PDE IV's role in sympathetic regulation of cardiac contractility.
PDE IV inhibitors exert a positive inotropic effect in the presence of cyclic AMP-dependent positive inotropic agents, suggesting PDE IV plays a role in regulating cardiac contraction during sympathetic stimulation.
Müller et al. (1990) studied this question.
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