March 22, 2019Frontiers in PharmacologyOpen Access

Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

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Why the study?

This study was designed to investigate the hemodynamic effect of the PDE4 inhibitor rolipram in normal rat hearts both in vivo and in vitro and its underlying mechanism.

Does rolipram improve cardiac contractility in normal rat hearts?

Population

Normal rat hearts

Comparison

Rolipram vs control

Design

In vivo and in vitro animal experimental study

Authors

HHHuili HuangChangchun University of Chinese Medicine MXMing XieJiangyin People's Hospital GLGao LiSouthwest University

Discussion

Member takes

Implication

Rolipram improves contractility in normal rat hearts; hypothesis-generating for PDE4 inhibition in heart failure models.

Structured PICO

Does rolipram improve cardiac contractility in normal rat hearts?

Population

Male Sprague Dawley rats (300–350 g) and isolated rat hearts/ventricular myocytes

Intervention

Rolipram (PDE4 inhibitor) 3 mg/kg intraperitoneally for in vivo studies, and 0.1, 1, 10 µM for in vitro studies

Comparator

Vehicle control (DMSO)

Outcome

Hemodynamic parameters (stroke work, cardiac output, stroke volume, ejection fraction, +dp/dtmax) and Ca2+ transient mechanismssurrogate

Rolipram exerts a positive inotropic effect in rat hearts by enhancing SERCA2a activity, suggesting PDE4 inhibition as a potential target for heart failure.

Cite This Study

Huang et al. (2019) studied this question.

synapsesocial.com/papers/6a849bb889e830078fbcc076 https://doi.org/10.3389/fphar.2019.00221

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Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider