Key result
Surgical trauma induced immediate hyperglycemia and increased gut proteolysis (accounting for nearly 40% of whole body proteolysis), which shifted to skeletal muscle breakdown by 3 days postoperatively.
Population
Mongrel dogs (n = 5-8 per group)
Design
Preclinical
Follow-up
2 weeks
Authors
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Animal model data suggest early gut proteolysis may predominate; leaves open human translation for perioperative nutrition.
The gut acts as a major reservoir of amino acids during the immediate postoperative period following laparotomy, accounting for over one-third of whole body proteolysis.
Molina et al. (1998) studied Surgical trauma. Surgical trauma (laparotomy) was evaluated on Rates of whole body proteolysis and glucose turnover. Surgical trauma induced immediate hyperglycemia and increased gut proteolysis (accounting for nearly 40% of whole body proteolysis), which shifted to skeletal muscle breakdown by 3 days postoperatively.
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