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May 26, 2011International Journal of Molecular MedicineOpen Access

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

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Key result

Administration of an anti-periostin antibody (PN1-Ab) significantly inhibited primary tumor growth, lung metastasis, and bone destruction, resulting in increased survival in a murine breast cancer model.

Why the study?

Does a neutralizing antibody against periostin (PN1-Ab) reduce tumor progression and metastasis in a murine breast cancer model?

Population

In vitro 4T1 mouse breast cancer cells and in vivo female BALB/c mice inoculated with 4T1 cells.

Comparison

Neutralizing antibody against full-length… vs Control IgG.

Design

Preclinical

Follow-up

Up to 4 weeks

Authors

RMRyuichi MorishitaVascular / Pulmonary Vascular

Discussion

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Member takes

Implication

Supports periostin targeting in breast cancer models; leaves open translation to human trials.

Structured PICO

Does a neutralizing antibody against periostin (PN1-Ab) reduce tumor progression and metastasis in a murine breast cancer model?

P
Population
Female BALB/c mice inoculated with 4T1 breast cancer cells to model primary tumor growth and lung metastasis.
I
Intervention
Neutralizing antibody against full-length periostin (PN1-Ab) administered via cervical vein or intraperitoneally (e.g., 20 µg or 40 µg).
C
Comparator
Control IgG.
O
Outcome
Primary tumor growth, number of lung metastatic colonies, bone destruction, and overall survival.surrogate

Main Result

p-value: p=<0.05

Targeting full-length periostin with a neutralizing antibody inhibits tumor growth, metastasis, and bone destruction in a murine breast cancer model.

Limitations

  • Animal model results may not directly translate to human breast cancer
  • Further development of a humanized antibody is required for clinical application

Cite This Study

Ryuichi Morishita (2011) studied Breast cancer. Anti-periostin antibody (PN1-Ab) vs. Control IgG was evaluated on Tumor growth, metastasis, and survival (p=<0.05). Administration of an anti-periostin antibody (PN1-Ab) significantly inhibited primary tumor growth, lung metastasis, and bone destruction, resulting in increased survival in a murine breast cancer model.

synapsesocial.com/papers/6a9c9eaec6168cc7c6979706https://doi.org/10.3892/ijmm.2011.712
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Periostin is essential for cardiac healing after acute myocardial infarction2008 · 22 citations
  2. 2Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer2006 · 171 citations
  3. 3Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer2006 · 216 citations
  4. 4Role of alternative splicing of periostin in human bladder carcinogenesis2008 · 64 citations
  5. 5Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies2005 · 101 citations