Key result
Cell and growth factor-based therapies stimulate endogenous mechanisms of myocardial repair, with paracrine secretion playing a major role in the beneficial outcomes of cell transplantation.
Why the study?
Does cell transplantation improve myocardial repair and regeneration compared to growth factor administration in injured myocardium?
Does cell transplantation improve myocardial repair and regeneration compared to growth factor administration in injured myocardium?
This review highlights that the beneficial effects of cell transplantation for myocardial regeneration are primarily driven by paracrine mechanisms rather than direct cell replacement.
Paracrine mechanisms may underlie cell therapy benefits in myocardial repair; leaves open whether growth factors alone suffice, warranting prospective trials.
It has been recently established that the adult heart harbors a reservoir of myocardial stem/progenitor cells. The regenerative potential of the heart is, however, insufficient to fully restore the functional myocardium after damage, motivating the use of cell-and growth factor-based replacement strategies. In this review, we summarize the progress that has been made in this field and discuss its actual contribution to the stimulation of endogenous mechanisms of myocardial repair/regeneration. Particular emphasis has been paid to paracrine secretion occurring in host tissues as the major mechanism involved in the beneficial outcomes of cell transplantation into the injured myocardium. The advantages of using cell therapy over single and combined growth factor administration have been also extensively discussed.
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Chiara Sassoli (2013) conducted a review in Myocardial damage. Cell and growth factor-based therapies was evaluated. Cell and growth factor-based therapies stimulate endogenous mechanisms of myocardial repair, with paracrine secretion playing a major role in the beneficial outcomes of cell transplantation.
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