What question did this study set out to answer?

Determine whether male and female serum concentrations of persistent organochlorine pollutants (CB-153 and p,p'-DDE) are associated with prolonged time to pregnancy.

December 16, 2005Human Reproduction

Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)

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Determine whether male and female serum concentrations of persistent organochlorine pollutants (CB-153 and p,p'-DDE) are associated with prolonged time to pregnancy.
Analyzed serum concentrations of CB-153 and p,p'-DDE in blood samples collected from pregnant women and their partners.
Assessed couple fecundity via time to pregnancy across cohorts from Greenland, Warsaw, Kharkiv, and Swedish fishermen's wives (N=778 men, N=1505 women).
Couples from Warsaw, Kharkiv, and Sweden exhibited no association between male or female POP exposure and time to pregnancy.
Greenlandic men and women showed an association between elevated serum CB-153 and p,p'-DDE concentrations and prolonged time to pregnancy.
Strong intra-individual correlation between CB-153 and p,p'-DDE in Greenland precluded isolating the risk contribution of each individual compound or their interaction.

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Implication

Observational study finds prolonged time to pregnancy linked to organochlorine exposure in Greenland couples, suggesting dietary pollutants may impair human fertility.

Cite This Study

Axmon et al. (2005) studied this question.

synapsesocial.com/papers/6a9ca000c42eb00825f7bb1a https://doi.org/10.1093/humrep/dei397

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Implication

Observational study finds prolonged time to pregnancy linked to organochlorine exposure in Greenland couples, suggesting dietary pollutants may impair human fertility.

Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)

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Discussion

Implication

Cite This Study

Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)

Key Points

Discussion

Implication

Cite This Study

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