Key result
Among 6 patients with fulminant giant cell myocarditis requiring mechanical circulatory support, 5 showed improved cardiac function with immunosuppressive therapy, and 3 treated with dual immunosuppressants achieved >1-year survival.
Why the study?
The therapeutic strategy for giant cell myocarditis remains controversial.
Does mechanical circulatory support combined with immunosuppression improve survival in patients with fulminant giant cell myocarditis?
Population
6 consecutive Japanese patients with GCM requiring percutaneous mechanical circulatory support
Design
Single-center retrospective study
Authors
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May support immunosuppression with MCS for recovery in fulminant giant cell myocarditis; leaves open need for prospective validation.
Observational (n=6)
No
Does mechanical circulatory support combined with immunosuppression improve survival in patients with fulminant giant cell myocarditis?
In patients with fulminant giant cell myocarditis, early administration of cyclosporine-based immunosuppression combined with mechanical circulatory support may facilitate cardiac recovery and improve survival.
Nakajima-Doi et al. (2020) conducted an observational in Giant Cell Myocarditis (n=6). Mechanical circulatory support combined with immunosuppression was evaluated on Clinical and disease outcomes (survival and cardiac function recovery). Among 6 patients with fulminant giant cell myocarditis requiring mechanical circulatory support, 5 showed improved cardiac function with immunosuppressive therapy, and 3 treated with dual immunosuppressants achieved >1-year survival.
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