Key result
ACE II vs DD and ADD1 GlyGly vs TrpTrp polymorphisms were significantly associated with blood pressure changes during hydrochlorothiazide therapy (ACE II vs DD SMD 0.256; 95% CI 0.109-0.403).
Why the study?
Do ACE I/D and ADD1 Gly460Trp polymorphisms affect blood pressure response to hydrochlorothiazide in patients with uncomplicated hypertension?
Meta-Analysis (n=1,439)
Do ACE I/D and ADD1 Gly460Trp polymorphisms affect blood pressure response to hydrochlorothiazide in patients with uncomplicated hypertension?
ACE I/D and ADD1 Gly460Trp polymorphisms are significantly associated with the blood pressure response to hydrochlorothiazide in patients with uncomplicated hypertension.
Hydrochlorothiazide (HCTZ) is used to treat uncomplicated hypertension. However, many studies have reported the variance of inter-individual response to HCTZ. A meta-analysis of published data was conducted to evaluate the pharmacogenetic associations of ACE I/D and ADD1 Gly460Trp polymorphisms with blood pressure changes during HCTZ therapy. To analyze the influence of ACE I/D polymorphism, 4 studies including 1,439 patients were assessed and the 3 genotypes were compared (II vs. ID, II vs. DD, and ID vs. DD) with respect to blood pressure changes. A significant association between ACE and blood pressure change was observed for the comparison of the II and DD (standard differences in means = 0.256; 95% CI, 0.109 - 0.403). For ADD1 Gly460Trp polymorphism, 4 studies including 1,001 patients were assessed, and GlyGly vs. GlyTrp, GlyGly vs. TrpTrp and GlyTrp vs. TrpTrp genotype comparisons were analyzed. A significant association between ADD1 and blood pressure change was observed for the comparisons of GlyGly vs. GlyTrp (standard differences in means= 2.78; 95% CI, 0.563 - 4.99) and GlyGly vs. TrpTrp (standard differences in means = 1.80; 95% CI, 1.38 - 2.22). This study is the first meta-analysis to evaluate the influences of ACE and ADD1 polymorphisms on blood pressure responses to HCTZ to combine the inconsistent results of previous studies.
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Choi et al. (2013) conducted a meta-analysis in uncomplicated hypertension (n=1,439). ACE I/D and ADD1 Gly460Trp polymorphisms vs. Alternative genotypes (e.g., DD, TrpTrp) was evaluated on blood pressure changes during HCTZ therapy (SMD 0.256, 95% CI 0.109 - 0.403). ACE II vs DD and ADD1 GlyGly vs TrpTrp polymorphisms were significantly associated with blood pressure changes during hydrochlorothiazide therapy (ACE II vs DD SMD 0.256; 95% CI 0.109-0.403).
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