Key result
The ACE I/D polymorphism, but not the CYP11B2 -344T/C polymorphism, was significantly associated with systolic blood pressure response to hydrochlorothiazide (P=0.009).
Why the study?
Are ACE I/D and CYP11B2 -344T/C polymorphisms associated with systolic blood pressure response to hydrochlorothiazide in Han Chinese patients with essential hypertension?
Cohort (n=829)
Are ACE I/D and CYP11B2 -344T/C polymorphisms associated with systolic blood pressure response to hydrochlorothiazide in Han Chinese patients with essential hypertension?
The ACE I/D polymorphism may serve as a pharmacogenetic marker for predicting systolic blood pressure response to hydrochlorothiazide in Han Chinese patients with essential hypertension.
ACE I/D polymorphism was associated with hydrochlorothiazide response; leaves open its utility as pharmacogenetic marker pending validation.
To valuate whether angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and aldosterone synthase (CYP11B2) gene -344T/C polymorphism are associated with individual response to hydrochlorothiazide (HCTZ) in the Han Chinese population with essential hypertension. We enrolled 829 mild/moderate hypertensive patients and 12.5 mg of HCTZ was given daily. After 6 weeks, the results showed that the ACE I/D polymorphism, not the CYP11B2 -344T/C polymorphism, was associated with systolic blood pressure (SBP) response to HCTZ (P = 0.009) in the Han Chinese population with essential hypertension, with no interaction.
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Li et al. (2011) conducted a cohort in essential hypertension (n=829). ACE I/D and CYP11B2 -344T/C polymorphisms was evaluated on systolic blood pressure (SBP) response to HCTZ (p=0.009). The ACE I/D polymorphism, but not the CYP11B2 -344T/C polymorphism, was significantly associated with systolic blood pressure response to hydrochlorothiazide (P=0.009).
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