Comment on Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl- d -Aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro

We are writing to express our merit-based concerns about the study “Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N -Methyl- d -aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro ” by Valente et al . recently published in ACS Nano 2020, 14, 6866–6877. There are numerous reasons for which to believe that this study on conopeptide-functionalized gold nanoparticles is fundamentally flawed, contains incorrect or misleading statements, and its title and conclusions are not supported by the data presented.