Key result
High geomagnetic field disturbance was associated with a significant increase in mean arterial pressure (99 vs. 83 mm Hg, P=0.045) and myocardial oxygen consumption in sedated rabbits.
Absolute Event Rate: 99% vs 83%
p-value: p=0.045
Geomagnetic field disturbances may affect cardiovascular regulation by modulating arterial baroreflex sensitivity and increasing blood pressure and myocardial oxygen consumption in a rabbit model.
May elevate arterial pressure in rabbits during geomagnetic disturbance; leaves open human relevance and requires prospective validation.
The goal of the present research was try to explain the physiological mechanism for the influence of the geomagnetic field (GMF) disturbance, reflected by the indices of the geomagnetic activity (K, K(p), A(k), and A(p) indices), on cardiovascular regulation. One hundred forty three experimental runs (one daily) comprising 50 min hemodynamic monitoring sequences were carried out in rabbits sedated by pentobarbital infusion (5 mg/kg/h). We examined the arterial baroreflex effects on the short term blood pressure and heart rate (HR) variabilities reflected by the standard deviation (SD) of the average values of the mean femoral arterial blood pressure (MAP) and the HR. Baroreflex sensitivity (BRS) was estimated from blood pressure/HR response to intravenous (i.v.) bolus injections of vasoconstrictor (phenylephrine) and vasodilator (nitroprusside) drugs. We found a significant negative correlation of increasing GMF disturbance (K(p)) with BRS (P = 0.008), HR SD (P =0.022), and MAP SD (P = 0.002) signifying the involvement of the arterial baroreflex mechanism. The abrupt change in geomagnetic disturbance from low (K = 0) to high (K = 4-5) values was associated with a significant increase in MAP (83 +/- 5 vs. 99 +/- 5 mm Hg, P = 0.045) and myocardial oxygen consumption, measured by MAP and HR product (24100 +/- 1800 vs. 31000 +/- 2500 mm Hg. bpm, P = 0.034), comprising an additional cardiovascular risk. Most likely, GMF affects brainstem and higher neural cardiovascular regulatory centers modulating blood pressure and HR variabilities associated with the arterial baroreflex.
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Gmitrov et al. (2004) studied Geomagnetic field disturbance (n=143). High geomagnetic field disturbance (K = 4-5) vs. Low geomagnetic disturbance (K = 0) was evaluated on Mean femoral arterial blood pressure (MAP) (p=0.045). High geomagnetic field disturbance was associated with a significant increase in mean arterial pressure (99 vs. 83 mm Hg, P=0.045) and myocardial oxygen consumption in sedated rabbits.
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