Why the study?
Does increased end-organ vascular resistance reduce poststenotic peak systolic velocity in an in vitro hydraulic model of renal arterial stenosis?
Does increased end-organ vascular resistance reduce poststenotic peak systolic velocity in an in vitro hydraulic model of renal arterial stenosis?
Increased end-organ vascular resistance mildly decreases poststenotic peak systolic velocity, partially explaining variability in Doppler US detection of renal artery stenosis.
Higher end-organ resistance may mildly lower poststenotic PSV in renal stenosis models; hypothesis-generating for Doppler diagnostic variability.
PURPOSE: To test the hypothesis that increased end-organ vascular resistance reduces blood flow to the kidney, thus reducing the mean velocity in the renal artery and secondarily lowering the peak systolic velocity (PSV). MATERIALS AND METHODS: An in vitro hydraulic model with a pulsatile pump, blood-mimicking fluid, interchangeable stenoses, and variable compliance and resistance was used to investigate the relationship between end-organ vascular resistance and poststenotic PSV. RESULTS: Poststenotic PSV was mildly dependent on end-organ vascular resistance and decreased with increasing resistance. CONCLUSION: The results help explain some of the reported variability from using poststenotic PSV to detect hemodynamically significant renal arterial stenoses, but the effect is not great enough to completely explain the variability. Other factors not investigated in this study must be at work as well.
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Bude et al. (1999) studied this question.
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