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The pK a values were determined for 10 guaiacyl phenols by UV spectrophotometric and potentiometric titration in the water—dioxane binary system over the composition range 0–80% organic solvent. The differentiating action of the solvent and para-substituent effects on the acidity of guaiacol derivatives were analyzed. The dependences of acidity constants on the mixed solvent composition were interpreted using the preferential solvation model.
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Боголицын et al. (2008) studied this question.
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