Key result
Adriamycin, DTIC, and/or vinblastine therapy for Hodgkin's disease was implicated as the potential cause of a fatal case of acute hepatic vein thrombosis.
Adriamycin, DTIC, and/or vinblastine therapy for Hodgkin's disease may be associated with fatal acute hepatic vein thrombosis.
Alerts clinicians to possible hepatic vein thrombosis with these agents; hypothesis-generating and requires confirmation.
A case of fatal acute hepatic vein thrombosis occurred during treatment for Hodgkin's disease. At necropsy no evidence of Hodgkin's disease or obliterative venoocclusive disease of the liver was found. We speculate that Adriamycin, DTIC and/or vinblastine may have been responsible for this unusual disorder.
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Houghton et al. (1979) studied this question. Adriamycin, DTIC, and/or vinblastine therapy for Hodgkin's disease was implicated as the potential cause of a fatal case of acute hepatic vein thrombosis.
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