Conjugate Allylation to α,β‐Unsaturated Aldehydes with the New Chemzyme p‐F‐ATPH

Success at last: The 1,4-allylation of α,β-unsaturated aldehydes with selectivities up to 95/5 and yields of 83% has been achieved thanks to the newly developed Lewis acidic receptor p-F-ATPH (L = 2,6-(pFC6H4)2C6H3O−. In addition to a coordination site for the aldehyde, this possesses an appropriate coordination site for a reactive nucleophile, as shown schematically on the right.