Asymmetric Hydrogenation of Cyclic Ketimines Catalyzed by Iridium(I)-Complexes of BCPM and Its Analog1

All articles of this category Modified pyrrolidinebisphosphines, BCPM ( 1a ) and its analog MCCPM ( 1b ), were found to be more efficient ligands than the original BPPM ( 2a ) in the iridium(I)-catalyzed asymmetric hydrogenation of imines in the presence of iodide. In particular, the modified ligands ( 1a,b ) showed very high enantioselectivity of up to 91% ee in the hydrogenation of 2,3,3-trimethylindolenine ( 6 ) in the presence of bismuth(III) iodide. asymmetric hydrogenation - imine - pyrrolidinebisphosphine - iridium complex - catalyst