Key result
Mitral valve replacement using newly developed porcine bioprosthetic valves in dogs showed normal short-term function without thrombosis or regurgitation, with pressure half time significantly increasing from 31.40 to 99.20 msec at 7 days (P<0.05).
Mitral valve replacement using newly developed porcine bioprosthetic valves under cardiopulmonary bypass is feasible and shows acceptable short-term hemodynamic performance in a healthy canine model.
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Short-term canine success supports further bioprosthetic valve development; leaves open human translation pending long-term safety data.
Porcine bioprosthetic valves cross-linked with glutaraldehyde and polyepoxy compound were newly developed for mitral valve replacement (MVR) in dogs. Five beagle dogs were performed a left thoracotomy and underwent MVR using the porcine bioprosthetic valves during cardiopulmonary bypass (CPB). A vein catheter inserted into right atrium and a vent catheter inserted into the right ventricle to drain. The hemodynamic conditions of CPB were excellent during surgery. The left atrial pressure was measured before and after MVR; there was no significant difference and it was normal. Thrombosis and the prosthetic valve regurgitation were not observed one week after MVR. Pressure half time (PHT) prolonged significantly (P<0.05) from 31.40 +/- 4.0 msec presurgery to 99.20 +/- 19.4 msec at seven days after MVR, although it indicated the normal range as the bioprosthetic valve. The symptom of the prosthetic valve failure was not observed. This study indicated that the MVR using porcine bioprosthetic valves under CPB might have been effective in dogs as a short-term evaluation.
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TAKASHIMA et al. (2007) studied Mitral regurgitation (experimental model) (n=5). Mitral valve replacement with porcine bioprosthetic valves vs. Baseline (presurgery) was evaluated on Pressure half time (PHT) (p=<0.05). Mitral valve replacement using newly developed porcine bioprosthetic valves in dogs showed normal short-term function without thrombosis or regurgitation, with pressure half time significantly increasing from 31.40 to 99.20 msec at 7 days (P<0.05).
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