Key result
Interaction of p130Cas with focal adhesion kinase (FAK) at Z-lines is critical for sarcomeric assembly and endothelin-induced hypertrophic gene expression in cultured cardiac myocytes.
Population
Neonatal cardiac myocytes in culture
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for myocyte hypertrophy mechanisms and requires in vivo validation.
The assembly of signaling complexes including Cas, FAK, and paxillin at Z-lines in cardiac myocytes regulates cytoskeletal organization and gene expression associated with hypertrophy.
Kovačič-Milivojević et al. (2001) studied Cardiac myocyte hypertrophy (in vitro model). Endothelin (ET) stimulation and FAK/Cas mutant expression vs. Untreated or GFP-infected control cells was evaluated on Sarcomeric organization and ANP/BNP gene expression. Interaction of p130Cas with focal adhesion kinase (FAK) at Z-lines is critical for sarcomeric assembly and endothelin-induced hypertrophic gene expression in cultured cardiac myocytes.
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