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January 1, 2025RSC Medicinal ChemistryOpen Access

Design, synthesis, and biological evaluation of novel N -(1 H -indazol-6-yl)benzenesulfonamide derivatives as potent PLK4 inhibitors

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Authors

PSPengkun SunShenyang Pharmaceutical University CFCunzheng FanShenyang Pharmaceutical University NLNian LiuShenyang Pharmaceutical University

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Implication

Preclinical drug evaluation reveals novel indazole benzenesulfonamide derivatives as potent PLK4 inhibitors, highlighting potential pathways to modulate mitosis and maintain genomic integrity.

Key Points

To design, synthesize, and biologically evaluate novel N-(1H-indazol-6-yl)benzenesulfonamide derivatives as targeted inhibitors of polo-like kinase 4 (PLK4).
Designed and synthesized chemical derivatives based on an N-(1H-indazol-6-yl)benzenesulfonamide core scaffold.
Evaluated biological activity targeting PLK4, a centrosomal serine/threonine protein kinase essential for mitotic cell division and genomic stability.
Identified novel benzenesulfonamide derivatives functioning as potent inhibitors against PLK4 kinase.
Established scaffold viability for disrupting centrosomal kinase activity necessary for proper mitotic regulation.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/6a9cb4d9f4d73a8d7859895e https://doi.org/10.1039/d5md00251f

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Implication

Preclinical drug evaluation reveals novel indazole benzenesulfonamide derivatives as potent PLK4 inhibitors, highlighting potential pathways to modulate mitosis and maintain genomic integrity.

Design, synthesis, and biological evaluation of novel N -(1 H -indazol-6-yl)benzenesulfonamide derivatives as potent PLK4 inhibitors

Discussion

Member takes

Implication

Key Points

Cite This Study

Design, synthesis, and biological evaluation of novel N -(1 H -indazol-6-yl)benzenesulfonamide derivatives as potent PLK4 inhibitors

Discussion

Member takes

Implication

Key Points

Cite This Study

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