Key result
Chronic severe mitral regurgitation patients had similar maximum myocardial stiffness compared to normal subjects (1398 vs 1165; NS), showing contractile function is often normal when EF is normal.
Why the study?
Does normal pump function belie muscle dysfunction in patients with chronic severe mitral regurgitation?
Population
27 patients with chronic severe mitral regurgitation and 23 normal subjects
Comparison
Left ventricular cineangiography and… vs Normal subjects (n=23)
Design
Cross-sectional
Authors
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Normal EF signals preserved myocardial stiffness in chronic severe MR; leaves open whether stiffness refines intervention timing beyond EF.
Observational (n=50)
Does normal pump function belie muscle dysfunction in patients with chronic severe mitral regurgitation?
Absolute Event Rate: 1398% vs 1165%
p-value: p=NS
In patients with chronic severe mitral regurgitation, contractile function is frequently normal when EF is normal, and depressed when EF is depressed, though this does not preclude satisfactory surgical outcomes.
Thomas Wisenbaugh (1988) conducted an observational in chronic severe mitral regurgitation (n=50). Chronic severe mitral regurgitation vs. Normal subjects was evaluated on Maximum myocardial stiffness (maxEN) (p=NS). Chronic severe mitral regurgitation patients had similar maximum myocardial stiffness compared to normal subjects (1398 vs 1165; NS), showing contractile function is often normal when EF is normal.
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