The synthesis of amoamine B (4), which inhibits the catalytic activity of topoisomerase II and exhibits selective cytotoxicity against human tumor cell lines, was achieved in four steps from 4-bromo-8-methoxy-6-methyl-5-nitroquinoline (6). The related compounds 11∼14 were also synthesized, and the antimicrobial activities of 4 and its seven related compounds 6, 8, 9, and 11-14 were investigated.
No takes yet. Share an insight, caveat, or question.
Nakahara et al. (2007) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: