Chemistry of Indoles Carrying a Basic Function. Part IV. Synthesis of D-Nor- ergoline and Ergoline Ring by Stobbe Reaction

Startjng from Uhle's ketone (2), pentacyclic lactone derivatives with D-norergoline ring (13 and 14) have been prepared by an unusual intramolecular Stohhe reaction of a succinic diester derivative (3a).The preparation of ergoline ring (1) itself was also achieved through modification of the reaction conditions.