Key result
Intracoronary bone marrow cell transplantation caused the greatest cardiac repair after myocardial infarction in swine with better intrinsic collateral vessels.
Why the study?
Does intracoronary transplantation of bone marrow CD34+ progenitor cells improve cardiac repair in a swine model of myocardial infarction?
Does intracoronary transplantation of bone marrow CD34+ progenitor cells improve cardiac repair in a swine model of myocardial infarction?
The presence of intrinsic collateral vessels enhances the efficacy of intracoronary bone marrow CD34+ progenitor cell transplantation for cardiac repair after myocardial infarction in a swine model.
Collateral status may guide cell therapy selection post-MI; leaves open translation beyond this swine model.
The effects of bone marrow cell transplantation (BMT) on myocardial infarct might be affected by host intrinsic circumferences. A best vascular niche was shown in the infarcted hearts with collateral vessels at 2 weeks after myocardial infarction (MI). BMT caused the greatest cardiac repairs after MI in the swine with better collateral vessels, which might be relative to richer collateral vessels, greater vessel densities, and higher expressions of basif fibroblast growth factor and stromal cell-derived factor-1 in the hearts before BMT. Our data suggest that existence of intrinsic collateral vessels contributes greatly to the beneficial effects of intracoronary BMT on cardiac repairs after MI. Disclosure of potential conflicts of interest is found at the end of this article.
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Zhang et al. (2007) studied Myocardial infarction. Intracoronary Transplantation of Bone Marrow CD34+ Progenitor Cells was evaluated on Cardiac repair. Intracoronary bone marrow cell transplantation caused the greatest cardiac repair after myocardial infarction in swine with better intrinsic collateral vessels.
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