Key result
Glucose-insulin-potassium (GIK) infusions did not reduce infarct size in an experimental dog model of myocardial infarction.
Why the study?
Does glucose-insulin-potassium (GIK) infusion reduce infarct size in an experimental dog model of myocardial infarction?
Does glucose-insulin-potassium (GIK) infusion reduce infarct size in an experimental dog model of myocardial infarction?
In an experimental dog model of myocardial infarction, glucose-insulin-potassium infusions failed to reduce infarct size.
The effect of glucose-insulin-potassium (GIK) infusions was studied in 45 dogs after left anterior descending coronary artery ligation. GIK caused a modest increase in lactate concentration in small veins draining the infarct but did not affect glucose uptake. No effect on creatine kinase activity in the infarct was seen from GIK, although there was a slight increase in blood flow to the centre of the infarct. We concluded that GIK did not reduce infarct size in this experimental model.
No takes yet. Share an insight, caveat, or question.
Heng et al. (1978) studied Experimental myocardial infarction (n=45). Glucose-insulin-potassium (GIK) infusions was evaluated on Infarct size. Glucose-insulin-potassium (GIK) infusions did not reduce infarct size in an experimental dog model of myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: