June 1, 1972Circulation
Effect of Glucose-Insulin-Potassium Infusion on Myocardial Infarction following Experimental Coronary Artery Occlusion
Why the study?
Does glucose-insulin-potassium infusion reduce myocardial necrosis in dogs with experimental coronary artery occlusion?
Population
37 dogs with experimental coronary artery occlusion
Comparison
Glucose-insulin-potassium infusion or glucose… vs Normal saline infusion (control group)
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in canine occlusion; leaves open whether GIK reduces necrosis in clinical infarction.
Key Points
- To assess the effects of glucose-insulin-potassium infusion on myocardial infarction in a canine model following coronary occlusion.
- Conducted on 37 dogs with experimental coronary artery occlusion.
- Infused glucose-insulin-potassium or glucose at specified intervals after occlusion.
- Evaluated myocardial creatine phosphokinase activity and histological changes 24 hours post-occlusion.
- In the GIK group, 36% of specimens showed normal histology, compared to 3% in controls; G group had 30% normal.
- CPK activity in the GIK group was significantly less depressive than controls (log CPK = –0.022 S-T + 1.25).
- Propranolol combined with GIK resulted in less CPK depression than controls.
Structured PICO
Does glucose-insulin-potassium infusion reduce myocardial necrosis in dogs with experimental coronary artery occlusion?
P
Population
37 dogs with experimental coronary artery occlusion
I
Intervention
Glucose-insulin-potassium (GIK) infusion or glucose (G) infusion started 30 min after occlusion, or GIK and propranolol (P) started 3 hours after occlusion
C
Comparator
Normal saline infusion (control group)
O
Outcome
Myocardial creatine phosphokinase (CPK) activity and morphologic changes at 24 hourssurrogate
Glucose-insulin-potassium infusion exerts a protective effect against myocardial ischemia and reduces the extent of myocardial necrosis following experimental coronary occlusion in dogs.
Cite This Study
Maroko et al. (1972) studied this question.