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January 12, 2005Journal of NeuroscienceOpen Access

Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance

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Authors

JXJennifer Y. XieArkansas State UniversityDHDavid S. HermanSamumed (United States)CSCarl‐Olav StillerKarolinska University Hospital

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Xie et al. (2005) studied this question.

synapsesocial.com/papers/6a9cbb2c3ac003e7df0302a5https://doi.org/10.1523/jneurosci.4054-04.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pronounced changes in the activity of nociceptive modulatory neurons in the rostral ventromedial medulla in response to prolonged thermal noxious stimuli1994 · 102 citations
  2. 2The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat1983 · 513 citations
  3. 3Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance2001 · 339 citations
  4. 4Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat2000 · 209 citations
  5. 5Morphine‐induced in vivo release of spinal cholecystokinin is mediated by δ‐opioid receptors – effect of peripheral axotomy2001 · 20 citations