The administration of selenium concomitantly with lead in rats restrained the lead induced enzymuria, proteinuria, enhanced urinary excretion of delta-aminolevulinic acid, inhibition of the activities of certain renal enzymes, blood delta-aminolevulinic acid dehydratase and blood, liver and kidney uptake of lead. The protective effect of selenium against lead toxicity may be attributed to a competition between selenium and lead for binding with the functional bioligands or to the in vivo formation of lead selenide.
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Flora et al. (1983) studied this question.
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