Key result
Twin pregnancies are associated with a 2 to 3-fold higher prevalence of preeclampsia (9-11%) compared to singleton pregnancies and exhibit earlier, more pronounced maternal cardiovascular maladaptations.
Why the study?
Twin pregnancies carry an increased risk and are affected in more significant numbers, earlier gestations, and more severely by preeclampsia.
Twin pregnancies impose a significantly greater cardiovascular burden than singletons, leading to earlier and more severe preeclampsia, which highlights the need for specific screening and management strategies.
Hypertensive disorders of pregnancy contribute significantly to maternal and perinatal mortality and morbidity. Twin pregnancies which already carry an increased risk to mothers and fetuses, are affected in more significant numbers, earlier gestations and more severely by preeclampsia. This narrative review assesses the current state of research on maternal haemodynamics in twin pregnancy and the specific changes in those affected by preeclampsia. We assessed current literature focusing on maternal haemodynamics, angiogenic markers and screening models in twin versus singleton pregnancies. Relevant literature was identified through a search of electronic databases using keywords such as "twin pregnancy", "preeclampsia" and "maternal haemodynamics". Studies were included based on their relevance to cardiovascular adaptation and clinical outcomes in twin pregnancy. We highlight the unique challenges of diagnosing and managing preeclampsia in twin pregnancies compared to singleton pregnancies.
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Hanton et al. (2026) conducted a review in Preeclampsia. Twin pregnancy vs. Singleton pregnancy was evaluated on Incidence of preeclampsia. Twin pregnancies are associated with a 2 to 3-fold higher prevalence of preeclampsia (9-11%) compared to singleton pregnancies and exhibit earlier, more pronounced maternal cardiovascular maladaptations.
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