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October 25, 2013Computer Methods in Biomechanics & Biomedical EngineeringOpen Access

Validation of numerical flow simulations againstin vitrophantom measurements in different type B aortic dissection scenarios

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Key result

Computational fluid dynamics simulations accurately predicted intra-luminal pressures in type B aortic dissection models with large tears, demonstrating average relative errors of less than 10% compared to in vitro measurements.

Why the study?

Does a computational fluid dynamic (CFD) tool accurately predict intra-luminal pressures compared to in vitro phantom measurements in type B aortic dissection scenarios?

Population

4 idealized dissected physical models of chronic type B aortic dissection with varying tear sizes and…

Comparison

Computational fluid dynamic simulations using a… vs In vitro experimental measurements on compliant…

Design

Preclinical

Authors

ESEduardo SoudahPRPaula A. RudenickMBMaurizio Bordone

Discussion

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Overview

May refine hemodynamic modeling in type B dissection; leaves open clinical adoption pending human validation.

Key Points

  • To validate a computational fluid dynamics tool against experimental in vitro measurements for characterizing hemodynamics across various type B aortic dissection geometries.
  • Conducted numerical computational fluid dynamics (CFD) simulations across multiple idealized aortic dissection geometries.
  • Compared numerical flow velocity and pressure profiles to benchtop experimental data obtained from physical phantom models.
  • Demonstrated good overall correlation between numerical flow simulations and physical in vitro measurements.
  • Identified that simulation accuracy depends on tear size, performing reliably when tears are sufficiently large to render vessel wall compliance effects negligible.

Structured PICO

Does a computational fluid dynamic (CFD) tool accurately predict intra-luminal pressures compared to in vitro phantom measurements in type B aortic dissection scenarios?

P
Population
In vitro and in silico study evaluating four idealized configurations of chronic type B aortic dissections.
I
Intervention
Computational fluid dynamic (CFD) simulations using a rigid-wall numerical model
C
Comparator
In vitro experimental measurements on compliant physical phantoms (latex and silicone)
O
Outcome
Intra-luminal pressure waveforms in the true lumen (TL) and false lumen (FL) at distal and proximal sitessurrogate

CFD simulations can accurately predict intra-luminal pressures in chronic type B aortic dissections with large tears, providing a potential tool for hemodynamic characterization.

Limitations

  • Use of a rigid computational model compared to a flexible physical phantom.
  • Retrograde catheterization in vitro may have caused partial obstruction of small tears.
  • Difficulty determining the exact position of the transducer inside the phantoms to exactly correlate in vitro measurements with in silico predictions.
  • Comparing a flexible physical phantom with a rigid computational model
  • Difficulty determining the exact position of the transducer inside the phantoms
  • Not an in vivo validation

Cite This Study

Soudah et al. (2013) studied Type B aortic dissection. Computational fluid dynamics (CFD) simulations vs. In vitro phantom measurements was evaluated on Intra-luminal pressure relative error. Computational fluid dynamics simulations accurately predicted intra-luminal pressures in type B aortic dissection models with large tears, demonstrating average relative errors of less than 10% compared to in vitro measurements.

synapsesocial.com/papers/6a9cbd05a2aa65bfe097a661https://doi.org/10.1080/10255842.2013.847095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute type B aortic dissection2011 · 21 citations
  2. 2The International Registry of Acute Aortic Dissection (IRAD)2000 · 3,664 citations
  3. 3Long-Term Survival in Patients Presenting With Type B Acute Aortic Dissection2006 · 770 citations
  4. 4Effect of medical and surgical therapy on aortic dissection evaluated by transesophageal echocardiography. Implications for prognosis and therapy. The European Cooperative Study Group on Echocardiography.1993 · 411 citations
  5. 5Long-Term Outcome of Aortic Dissection With Patent False Lumen2012 · 421 citations