Key result
High anger proneness and depressive symptoms were associated with increased risk of incident peripheral arterial disease (RR 1.38, 95% CI 1.08-1.76 and RR 1.44, 95% CI 1.19-1.74, respectively).
Why the study?
Are anger proneness, depression, and low social support associated with incident peripheral arterial disease in middle-aged adults?
Population
12,965 middle-aged adults with no prior history of peripheral arterial disease from the Atherosclerosis Risk…
Comparison
High or moderate levels of anger proneness and… vs Low levels of anger proneness and depressive…
Design
Cohort
Follow-up
mean 9.7 years
Authors
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May inform PAD risk assessment in middle-aged adults; leaves open whether targeting anger or depression prevents disease.
Cohort (n=12,965)
Yes
Are anger proneness, depression, and low social support associated with incident peripheral arterial disease in middle-aged adults?
Relative Risk: 1.38 (95% CI 1.08–1.76)
Anger proneness and depressive symptoms are independently associated with an increased risk of developing peripheral arterial disease in middle-aged adults.
Wattanakit et al. (2005) conducted a cohort in Peripheral arterial disease (n=12,965). Anger proneness and depressive symptoms vs. Low anger and low depressive symptoms was evaluated on incident PAD (ankle-brachial index <= 0.9; a hospital discharge diagnosis of PAD, leg amputation, or leg revascularization procedures; or intermittent claudication) (RR 1.38, 95% CI 1.08-1.76). High anger proneness and depressive symptoms were associated with increased risk of incident peripheral arterial disease (RR 1.38, 95% CI 1.08-1.76 and RR 1.44, 95% CI 1.19-1.74, respectively).
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