Key result
Metagenomic sequencing identified a pathogenic porcine rotavirus B strain (Buryat15) as the cause of an enteric disease outbreak in Russian weaning piglets, expanding its known global prevalence.
The identification and genomic characterization of a pathogenic porcine rotavirus B strain in Russia expands epidemiological knowledge of its global prevalence and genetic diversity.
May guide porcine rotavirus surveillance; extends global strain diversity data while leaving human relevance open.
An outbreak of enteric disease of unknown etiology with 60% morbidity and 8% mortality in weaning piglets occurred in November 2015 on a farm in Buryat Republic, Russia. Metagenomic sequencing revealed the presence of rotavirus B in feces from diseased piglets while no other pathogens were identified. Clinical disease was reproduced in experimentally infected piglets, yielding the 11 RVB gene segments for strain Buryat15, with an RVB genotype constellation of G12-P[4]-I13-R4-C4-M4-A8-N10-T4-E4-H7. This genotype constellation has also been identified in the United States. While the Buryat15 VP7 protein lacked unique amino acid differences in the predicted neutralizing epitopes compared to the previously published swine RVB G12 strains, this report of RVB in Russian swine increases our epidemiological knowledge on the global prevalence and genetic diversity of RVB.
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Alekseev et al. (2018) studied Enteric disease (Rotavirus B). Rotavirus B (strain Buryat15) was evaluated on Identification of pathogen and reproduction of clinical disease. Metagenomic sequencing identified a pathogenic porcine rotavirus B strain (Buryat15) as the cause of an enteric disease outbreak in Russian weaning piglets, expanding its known global prevalence.
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