Evaluation of platelet parameters in patients with gestational diabetes mellitus (GDM)

Aim: Gestational diabetes mellitus (GDM) is the most common metabolic disease during pregnancy. In our study, we evaluated the role of platelet large cell ratio (PLCR) and immature granulocytes (%IG) in GDM. Material and Method: Our study was conducted by retrospectively reviewing the records of 53 GDM patients between January 2019 and June 2020 at the clinics of Istanbul Training and Research Hospital. Thirty-eight healthy patients were included in the control group. GDM was diagnosed with 75g OGTT. The PLCR and IG% values obtained from the complete blood count of each patient performed in our hospital were studied. Results: Gestational diabetes mellitus was detected in 53 of 91 patients included in the study. The mean age in the GDM group was higher than in the non-GDM (control) group (32.85.0 /26.95.0, p<0.001). There was no statistical difference between the groups in gestational week (GW), body mass index (BMI) and PLCR parameters. Both IG% and HbA1c values were statistically significantly higher in the GDM group than in the non-GDM group (0.60.2/0.50.1, p=0.002; 5.40.8/5.10.3, p=0.005, respectively). In the ROC curve analysis, the area under the curve (AUC) for the IG% value to predict the presence of GDM was 0.713 (0.606-0.821). Discussion: This study investigated the values of PLCR and IG%, which are new inflammatory markers that have not been studied much, in GDM patients. We detected a statistically significant increase in IG% values in GDM patients and for the first time determined a cut-off value for this marker using ROC curve analysis.