Key result
High serum ADAMTS-5 levels were associated with significantly worse disease-free survival and a higher incidence of major adverse cardiovascular events compared to low levels in patients with acute myocardial infarction (p=0.0012).
Why the study?
This study explored the predictive value of plasma ADAMTS-5 levels for major adverse cardiovascular events in patients with coronary artery disease.
Does serum ADAMTS-5 level predict major adverse cardiovascular events and correlate with disease severity in patients with coronary artery disease?
Cohort (n=595)
No
Does serum ADAMTS-5 level predict major adverse cardiovascular events and correlate with disease severity in patients with coronary artery disease?
Elevated serum ADAMTS-5 levels correlate with CAD severity, higher SYNTAX scores, and worse 2-year clinical outcomes, suggesting its utility as a prognostic biomarker.
Answers are grounded in this paper and cite their sources.
May support ADAMTS-5 as a CAD prognostic biomarker; leaves open incremental value over existing scores in prospective cohorts.
This study explores the predictive value of plasma a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) levels for major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD). 595 patients admitted to our hospital were selected. Initially, the serum ADAMTS-5 levels of subjects were analyzed. Subsequently, a receiver operating characteristic (ROC) curve was constructed. Furthermore, the serum levels of ADAMTS-5 were assessed in patients, and based on CAD severity, they were categorized into stable angina pectoris (SAP), unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) groups, with the aim of examining the relationship between ADAMTS-5 levels and CAD severity. Differences in clinical outcomes between patients with high and low levels of ADAMTS-5 were analyzed during the follow-up period. The study found that the serum levels of ADAMTS-5 were significantly higher in the group of patients with coronary artery disease (CAD) compared to the group without CAD, indicating its potential as a diagnostic marker for CAD. The ADAMTS-5 levels in the serum of STEMI patients were higher than those with SAP, while NSTEMI patients showed higher levels of ADAMTS-5 than the UA group. There was a positive correlation between serum ADAMTS-5 levels and the syntax score in CAD patients, suggesting a potential association with adverse clinical outcomes in patients with acute myocardial infarction (AMI). This study indicates that ADAMTS-5 shows promise as a biomarker for CAD and highlights the need for further research and validation.
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Pan et al. (2023) conducted a cohort in Coronary Artery Disease (n=595). High serum ADAMTS-5 levels vs. Low serum ADAMTS-5 levels was evaluated on Disease-free survival (Major adverse cardiovascular events) (p=0.0012). High serum ADAMTS-5 levels were associated with significantly worse disease-free survival and a higher incidence of major adverse cardiovascular events compared to low levels in patients with acute myocardial infarction (p=0.0012).
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