Key result
The change in serum ADAMTS-7 levels from day 1 to day 7 after STEMI was independently associated with left ventricular reverse remodeling at 6 months (OR -0.322).
Why the study?
Does the change in serum ADAMTS-7 levels predict left ventricular reverse remodeling in patients with STEMI?
Cohort (n=167)
No
Does the change in serum ADAMTS-7 levels predict left ventricular reverse remodeling in patients with STEMI?
Odds Ratio: -0.322 (95% CI -0.996–-0.074)
p-value: p=0.028
A decrease in serum ADAMTS-7 levels from day 1 to day 7 after STEMI is independently associated with and predictive of left ventricular reverse remodeling at 6 months.
May support ADAMTS-7 for post-STEMI prognostication; hypothesis-generating pending validation in larger cohorts.
Left ventricular reverse remodeling (LVRR) in patients with ST-elevation myocardial infarction (STEMI) is associated with a good prognosis. Serum levels of ADAMTS-7 might be used for the prognosis of STEMI. This study aimed to investigate the relationship between serum ADAMTS-7 levels and LVRR. This was a prospective study of 104 patients with STEMI who underwent revascularization and 63 controls. ADAMTS-7 serum levels were measured on days 1, 3, and 7 and in months 1 and 6 after STEMI. A decrease ≥ 15% of the left ventricular end-systolic volume at 6 months was defined as LVRR. The serum levels of ADAMTS-7 in patients with LVRR were lower than those without LVRR (3.84 ± 2.26 vs. 5.02 ± 2.54, P = 0.032) 7 days after STEMI and the difference between day 7 and day 1 (ΔADAMTS-7) was even significantly lower (− 1.31 ± 0.94 vs. − 0.30 ± 0.22, P = 0.021). Multivariate analysis showed that ΔADAMTS-7 (day 7 minus day 1) was independently associated with LVRR (OR = − 0.322, 95% CI = − 0.996 to − 0.074, P = 0.028). Receiver operating characteristic (ROC) curve analysis showed that LVRR could be predicted (sensitivity 89%, specificity 82%, and area under the curve 0.896) when ΔADAMTS-7 (day 7 minus day 1) was < − 0.39. ΔADAMTS-7 (day 7 minus day 1) might be a potential predictive factor for LVRR.
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Wu et al. (2018) conducted a cohort in ST-elevation myocardial infarction (n=167). ΔADAMTS-7 (day 7 minus day 1) vs. Non-LVRR group was evaluated on Left ventricular reverse remodeling (LVRR) at 6 months (OR -0.322, 95% CI -0.996 to -0.074, p=0.028). The change in serum ADAMTS-7 levels from day 1 to day 7 after STEMI was independently associated with left ventricular reverse remodeling at 6 months (OR -0.322).
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