Key result
High total carbohydrate intake is linked to ~151% higher AF risk in men, but not women.
Why the study?
Evidence linking carbohydrate intake with incident atrial fibrillation remains limited.
Does high carbohydrate consumption increase the risk of incident atrial fibrillation in a Japanese urban population?
Cohort (n=5,229)
No
Does high carbohydrate consumption increase the risk of incident atrial fibrillation in a Japanese urban population?
High intake of total and simple carbohydrates is associated with an increased risk of incident atrial fibrillation in Japanese men, but not in women.
Answers are grounded in this paper and cite their sources.
Suggests caution with high carbohydrate intake in Japanese men; leaves open causality and need for confirmatory trials.
BACKGROUND AND AIM: Evidence of an association between carbohydrate intake and atrial fibrillation (AF) incidence remains limited. We investigated the association between carbohydrate and staple food consumption and AF risk in a Japanese urban population. METHODS AND RESULTS: Our population-based prospective cohort study included 5229 adult participants (mean age 56.9 years; 46.5% men) who completed a Food Frequency Questionnaire. Multivariable-adjusted Cox regression models were used to assess the association between carbohydrate intake (g/day) and staple food consumption (rice, noodles and bread) and AF incidence after adjusting for confounding factors. During 68 668 person-years of follow-up (mean, 13.1 years), 226 individuals developed AF. Total and simple carbohydrate intakes were associated with an increased AF risk in men (HR and 95% CI for Q4 vs Q1 were 2.51 (1.06 to 5.96) and 3.29 (1.33 to 8.13), respectively). In contrast, there were no significant associations between total carbohydrate, simple or complex carbohydrate intake and AF risk in women (HR and 95% CI for Q4 vs Q1 were 1.33 (0.27 to 6.65), 2.75 (0.74-10.26) and 1.04 (0.38-2.83), respectively). We found no association between staple foods and AF risk in men or women. CONCLUSIONS: Our findings imply that the association between carbohydrate intake and AF risk is influenced by the type of carbohydrates. We found a positive association between high intake of simple carbohydrates and AF risk in men whereas the association was negative for complex carbohydrate intakes. Meanwhile, the results in the women's group were inconclusive.
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Khairan et al. (2026) conducted a cohort in Atrial fibrillation (n=5,229). High carbohydrate intake (total and simple) vs. Lowest quartile of carbohydrate intake was evaluated on Incidence of atrial fibrillation (HR 2.51, 95% CI 1.06-5.96, p=0.04). High intake of total and simple carbohydrates was associated with a increased risk of atrial fibrillation in Japanese men, but not in women.
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