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March 1, 2017Journal of the American Heart AssociationOpen Access

In-hospital heart failure following acute myocardial infarction increased in-hospital mortality (OR 1.79; 95% CI 1.68-1.91), and postdischarge heart failure increased all-cause mortality (HR 5.98).

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Why the study?

Does the development of in-hospital or postdischarge heart failure increase mortality in patients with incident acute myocardial infarction?

Population

Patients hospitalized with an incident acute myocardial infarction and without a history of prior heart…

Comparison

Development of in-hospital heart failure or… vs AMI patients who did not develop heart failure.

Design

Cohort

Follow-up

up to 1 year after AMI discharge

Key result

In-hospital heart failure following acute myocardial infarction increased in-hospital mortality (OR 1.79; 95% CI 1.68-1.91), and postdischarge heart failure increased all-cause mortality (HR 5.98).

Authors

GSGerhard SuloJIJannicke IglandONOttar Nygård

Discussion

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Member takes

Overview

HF after AMI marks high short- and long-term mortality risk; leaves open whether targeted prevention improves survival.

Study Design

Type

Cohort

Multicenter

Yes

Structured PICO

Does the development of in-hospital or postdischarge heart failure increase mortality in patients with incident acute myocardial infarction?

P
Population
Patients hospitalized with an incident AMI and without history of prior HF hospitalization, followed up to 1 year after AMI discharge.
E
Exposure
Development of in-hospital heart failure (diagnosed during AMI hospitalization) or postdischarge heart failure (diagnosed within 1 year after discharge).
C
Comparator
AMI patients who did not develop heart failure.
O
Outcome
In-hospital mortality, 1-year all-cause mortality, and 1-year cardiovascular disease (CVD) mortality.hard clinical

Main Result

Odds Ratio: 1.79 (95% CI 1.68–1.91)

The development of heart failure, either during hospitalization for an acute myocardial infarction or within 1 year post-discharge, is associated with a substantially increased risk of short- and long-term mortality.

Cite This Study

Sulo et al. (2017) conducted a cohort in Acute Myocardial Infarction. Heart failure vs. No heart failure was evaluated on In-hospital mortality (OR 1.79, 95% CI 1.68-1.91). In-hospital heart failure following acute myocardial infarction increased in-hospital mortality (OR 1.79; 95% CI 1.68-1.91), and postdischarge heart failure increased all-cause mortality (HR 5.98).

synapsesocial.com/papers/6a9ccea42f6d620d5d2f0495https://doi.org/10.1161/jaha.116.005277
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